Organ bath physiology

In vitro motility

We use various sorts of organ baths to study the contractility of isolated stomach or gut preparations. In these experiments we analyse basal as well as nerval stimulated motility. Specific nerval stimulation is achieved with platinum electrodes. This model serves well to examine the effects of substances on phasic and tonic muscle activity under basal and stimulated circumstances.


Effect of a phytopharmacon on muscle tone in the guinea pig gastric corpus. Application of the substance (arrow left) triggers a relaxation. Washing out the substance with fresh nutrient solution completely reverses the effect.

Effect of the same substance in another stomach region: Here the substance evokes a rise in muscle tone. The figures also show another difference between the stomach regions: In contrast to the corpus, the antrum shows phasic contractions.